Commissural interneurons are key to 3D perception in binocular vision, but their precise function remain elusive. In zebrafish larva, we found inter-tectal commissural neurons (ITNs) essential for prey capture. To interrogate the molecular and cellular nature of these neurons, we developed transgenic tools targeting these cells in the tectum. The main goal of this project is investigate the genetic identity, connectivity and mechanisms of action of ITNs and to test whether dopamine or serotonin can alter ITN activity in order to modulate the success of prey capture.
- Dunn TW, Gebhardt C, Naumann EA, Riegler C, Ahrens MB, Eng ert F, Del Bene F . Neural Circuits Underlying Visually Evoked Escapes in Larval Zebrafish. Neuron. 2016, Feb 3;89(3):613-28. DOI:10.1016/j.neuron.2015.12.021.