Eyes 'n Tail

Eyes ’n Tail
Network mechanisms underlying the coordination of eye and tail movement

Action selection and the coordination of different behaviors are fundamental tasks of all nervous systems. We will use the larval zebrafish to study these questions.

When presented with wholefield visual motion, larval zebrafish perform either oculomotor or locomotor behaviors to stabilize the visual scene on the retina. This project will identify the visual features which differentially activate these two behaviors and aim to understand the neuronal circuitry and computations that underlie this dichotomy. Retinal ganglion cells project heterogeneously to ten regions in the brain called arborization fields (AFs) but the contribution of AFs to these behaviors is not yet understood. The project will involve behavioral, imaging and optogenetic approaches.

Publications

  • Publication 1: Dragomir EI, Štih V, Portugues R, Evidence accumulation during a perceptual decision task revealed by whole-brain imaging. [Under review].

  • Publication 2: Knogler LD, Kist AM, Portugues R (2019), Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours. eLife, doi:10.7554/eLife.42138.

  • Publication 3: Knogler LD, Markov AD, Dragomir EI, Štih V, Portugues R (2017), Sensorimotor representations in cerebellar granule cells in larval zebrafish are dense, spatially organized, and non-temporally patterned. Curr Biol 27: 1288-1302, doi: 10.1016/j.cub.2017.03.029.