Claire Wyart

Unravel circuits of exploration and modulation by internal and external cues

The Wyart lab (ICM, Paris, France) combines biophysics, electrophysiology, genetics and optogenetics, behavioral analysis and modeling to understand how internal and external sensory cues are integrated in motor circuits to tune the level and quality of locomotion based on the animal needs.

The Wyart lab investigates how internal and external sensory cues are integrated to shape movements and posture during active locomotion. We discovered a novel sensory system in the vertebrate spinal cord. We show that sensory neurons contacting the cerebrospinal fluid (CSF) together with the Reissner fiber detect changes of CSF flow associated with curvature of the spine. These interoceptor neurons modulate the activity of spinal interneurons controlling locomotion and posture. The Wyart lab has investigated the role of this novel sensory system in postural control, morphogenesis of the spine and detection of pathogens during infections of the nervous system. We are now eager to decipher in the brain the motor circuits controlling basic exploration and its modulation based on inner states and external sensory cues.

Publications

  • (poster) Gautam Sridhar, Gautam Reddy, João Marques, Rita Felix, Olivier Mirat, Michael Orger, Claire Wyart [2021]. Unsupervised statistical model based on language learning segments fundamental sequences of prey capture behaviour. NeuroFrance 2021 conference, 2021. ()
  • (poster) Xinyu Jia, Mathilde Lapoix, Martin Carbo-Tano, Claire Wyart [2021]. From birthdate to projection range: light on the functions of reticulospinal neurons. NeuroFrance 2021 conference. ()
  • Sternberg, J.R., Prendergast, A.E., Brosse, L., Cantaut-Belarif, Y., Thouvenin, O., Orts-Dell'Immagine, A., Castillo, L., Djenoune, L., Kurisu, S., McDearmid, J.R., Bardet, P.L., Boccara, C., Okamoto, H., Delmas, P., Wyart, C.# [2018]. Pkd2l1 is required for mechanoception in cerebrospinal fluid-contacting neurons and maintenance of spine curvature. Nature Communications 2018, 9:3804. DOI:10.1038/s41467-018-06225-x. ()

Contact

CHU Pitié Salpêtrière 47, bld hopital 75013 Paris FRANCE

Email: claire.wyart@gmail.com

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