David LyonsMechanisms of myelinated axon formation, health and function in vivo
The Lyons lab (UEDIN, Edinburgh, UK) investigates molecular, cellular and functional mechanisms underpinning neuron-glial interactions in vivo.
The Lyons lab studies neuron-glial interactions in the vertebrate nervous system, primarily using zebrafish as a model organism. The group is particularly interested in how neurons and glial cells interact to coordinate the formation of myelinated axons and maintain their health and function throughout life. The Lyons lab exploit the unique properties of zebrafish to combine chemical and genetic screening and targetting with live imaging of cell behaviour and in vivo functional analyses from subcellular through system levels.
Publication 1: Allen NJ, Lyons DA (2018). Glia as architects of nervous system formation and function. Science. 362(6411):181-185.
Publication 2: Baraban M, Koudelka S and Lyons DA. (2018). Ca2+ activity signatures of myelin sheath formation and growth in vivo. Nature Neuroscience21(1):19-23.
Publication 3: Koudelka S, Voas MG, Almeida RG, Baraban M, Soetaert J, Meyer MP, Talbot WS and Lyons DA (2016). Individual neuronal subtypes exhibit diversity in CNS myelination mediated by synaptic vesicle release. Current Biology 26(11):1447-55.