The Orger lab (CCU, Lisbon, Portugal) aims to understand how the brain integrates sensory information and selects and executes appropriate actions. We use zebrafish as a model because it allows us to record and manipulate activity through the whole brain, from input to output.
The Orger lab is located in the Champalimaud Centre for the Unknown, a research centre on the Lisbon Waterfront specializing in Neuroscience and Cancer Research. The Vision to Action Group aims to determine the principles governing the organization and function of neural circuits underlying visually guided behaviours. Our approach has three main themes: 1. High resolution quantitative analysis of behaviour. 2. Whole-brain imaging of neural activity dynamics. 3. Development of optical and genetic tools for more precise manipulations of neural circuits.
Publication 1: Marques JC, Lackner S, Félix R, & Orger MB† (2018). Structure of the Zebrafish Locomotor Repertoire Revealed with Unsupervised Behavioral Clustering. Current Biology, 28(2). 181-195.
Publication 2: de Polavieja GG, Orger MB (2017) Zebrafish behaviour: Opportunities and challenges. Annual Review of Neuroscience. 40, 125-147.
Publication 3: Portugues R, Feierstein CE, Engert F, Orger MB† (2014) Whole-brain activity maps reveal stereotyped, distributed networks for visuomotor behaviour. Neuron. 81(6): 1328-43.