Genetic Engineering
Fine kinematics analysis of genetic models of Parkinson's disease
Parkinson's disease is a progressive disorder of the nervous system with a multitude of symptoms and pathological hallmarks. Taking advantage of innovative genome editing techniques, we have generated genetic models of Parkinson's-associated genes in zebrafish. The goal is to use these models to perform thorough kinematic analyses of swimming behaviours across different developmental stages. The goal is to identify any Parkinsonian phenotypes and to ultimately perform drug screens using these zebrafish models.
Publications
- Jarque S, Ibarra J, Rubio-Brotons M, García-Fernández J, Terriente J. [2019]. Multiplex Analysis Platform for Endocrine Disruption Prediction Using Zebrafish. Int J Mol Sci. 2019, Apr 8;20(7).
- Pant DC, Dorboz I, Schlüter A, Fourcade S, Launay N, Joya J, Aguilera-Albesa S, Yoldi ME, Casasnovas C, Willis MJ, Ruiz M, Ville D, Lesca G, Siquier-Pernet K, Desguerre I, Yan H, Wang J, Burmeister M, Brady L, Tarnopolsky M, Cornet C, Rubbini D, Terriente J, James KN, Musaev D, Zaki MS, Patterson MC, Lanpher BC, Klee EW, Pinto E Vairo F, Wohler E, Sobreira NLM, Cohen JS, Maroofian R, Galehdari H, Mazaheri N, Shariati G, Colleaux L, Rodriguez D, Gleeson JG, Pujades C, Fatemi A, Boespflug-Tanguy O, Pujol A. [2019]. Loss of the sphingolipid desaturase DEGS1 causes hypomyelinating leukodystrophy. J Clin Invest, 2019 Jan 8.
- Cornet C, Di Donato V, Terriente J# [2018]. Combining Zebrafish and CRISPR/Cas9: Toward a More Efficient Drug Discovery Pipeline. Front Pharmacol, 2018 Jul 3.
